BU09059
Modify Date: 2024-09-29 19:03:06
BU09059 structure
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Common Name | BU09059 | ||
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| CAS Number | 1541206-05-6 | Molecular Weight | 495.62 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H37N3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BU09059BU09059 is a potent, selective, short-acting kappa-opioid receptor antagonist with Ki of 1.72 nM, displays 15- and 616-fold selectivity over μ- and δ-receptors respectively; BU09059 is a potent and selective κ-antagonist with pA2 of 8.62, significantly blocks U50,488-induced antinociception in vivo (3 and 10 mg/kg), demonstrates a shorter duration of κ-antagonist action in vivo. |
| Name | BU09059 |
|---|
| Description | BU09059 is a potent, selective, short-acting kappa-opioid receptor antagonist with Ki of 1.72 nM, displays 15- and 616-fold selectivity over μ- and δ-receptors respectively; BU09059 is a potent and selective κ-antagonist with pA2 of 8.62, significantly blocks U50,488-induced antinociception in vivo (3 and 10 mg/kg), demonstrates a shorter duration of κ-antagonist action in vivo. |
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| References | References 1. Casal-Dominguez JJ, et al. Send toACS Chem Neurosci. 2014 Mar 19;5(3):177-84. View Related Products by Target Opioid Receptor |
| Molecular Formula | C28H37N3O5 |
|---|---|
| Molecular Weight | 495.62 |
| InChIKey | RKGRJMYCISUSNK-XTNINKNLSA-N |
| SMILES | CCOC(=O)C(CN1CCC(C)(c2cccc(O)c2)C(C)C1)NC(=O)C1Cc2ccc(O)cc2CN1 |