Aminoethyl-SS-ethylalcohol

Modify Date: 2025-08-27 12:11:55

Aminoethyl-SS-ethylalcohol Structure
Aminoethyl-SS-ethylalcohol structure
Common Name Aminoethyl-SS-ethylalcohol
CAS Number 15579-01-8 Molecular Weight 153.27
Density N/A Boiling Point N/A
Molecular Formula C4H11NOS2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Aminoethyl-SS-ethylalcohol


Aminoethyl-SS-ethylalcohol (Compound 3) is an Alkyl-Chain-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminoethyl-SS-ethylalcohol is also a glutathione cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

 Names

Name Aminoethyl-SS-ethylalcohol

 Aminoethyl-SS-ethylalcohol Biological Activity

Description Aminoethyl-SS-ethylalcohol (Compound 3) is an Alkyl-Chain-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminoethyl-SS-ethylalcohol is also a glutathione cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog
Target

Alkyl-Chain

Cleavable

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References

[1]. Zhang H, et al. Striking a Balance between Carbonate/Carbamate Linkage Bond- and Reduction-Sensitive Disulfide Bond-Bearing Linker for Tailored Controlled Release: In Situ Covalent-Albumin-Binding Gemcitabine Prodrugs Promote Bioavailability and Tumor Accumulation. J Med Chem. 2018 Jun 14;61(11):4904-4917.

[2]. Yuelog Ma, et al. HUMANIZED LEWIS-Y SPECIFIC ANTIBODY-BASED DELIVERY OF DICER SUBSTRATE siRNA (D-siRNA) AGAINST STAT3. US20130052731A1.

 Chemical & Physical Properties

Molecular Formula C4H11NOS2
Molecular Weight 153.27
InChIKey OAHFAPXIBISUJB-UHFFFAOYSA-N
SMILES NCCSSCCO
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