4-IBP

Modify Date: 2024-01-02 23:58:16

4-IBP structure	Common Name	4-IBP
	CAS Number	155798-08-6	Molecular Weight	420.28700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₁IN₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 4-IBP

4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .IC50 value: 1.7 nM (Ki)Target: σ1in vitro: 4-IBP is a σ1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells. 4-IBP is used to investigate whether targeting theσ1 receptor could modify in vitro the migration rates of human cancer cells and increase the sensitivity of metastasizing human A549 NSCLC cells and infiltrating human glioblastoma cells to cytotoxic insults of either proapoptotic or proautophagic drugs.[1]in vivo: 4-IBP increases the antitumor effects of temozolomide and irinotecan in immunodeficient mice that were orthotopically grafted with invasive cancer cells.[1]

Name	N-(1-Benzyl-4-piperidinyl)-4-iodobenzamide
Synonym	More Synonyms

Description	4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .IC50 value: 1.7 nM (Ki)Target: σ1in vitro: 4-IBP is a σ1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells. 4-IBP is used to investigate whether targeting theσ1 receptor could modify in vitro the migration rates of human cancer cells and increase the sensitivity of metastasizing human A549 NSCLC cells and infiltrating human glioblastoma cells to cytotoxic insults of either proapoptotic or proautophagic drugs.[1]in vivo: 4-IBP increases the antitumor effects of temozolomide and irinotecan in immunodeficient mice that were orthotopically grafted with invasive cancer cells.[1]
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Sigma Receptor Research Areas >> Cancer
References	[1]. Mégalizzi V, et al. 4-IBP, a sigma1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vitro and sensitizes them in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs. Neoplasia. 2

Molecular Formula	C₁₉H₂₁IN₂O
Molecular Weight	420.28700
Exact Mass	420.07000
PSA	32.34000
LogP	4.01440
Storage condition	2-8°C

4-IBP

DC Chemicals Limited
China
Product Name: 4-IBP
Price: $450.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $92/10mM*1mLinDMSO

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4-IBP

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