(R)-3-Hydroxy Midostaurin

Modify Date: 2024-01-15 02:45:58

(R)-3-Hydroxy Midostaurin structure	Common Name	(R)-3-Hydroxy Midostaurin
	CAS Number	155848-20-7	Molecular Weight	586.64
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₅H₃₀N₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (R)-3-Hydroxy Midostaurin

(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1].

Name	(R)-3-Hydroxy Midostaurin

Description	(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3
In Vitro	(R)-3-Hydroxy Midostaurin ((R)-CGP52421; compound 5) has IC50 values in the range of 200-400 nM against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme[1]. The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ (GI50=63 nM), KIT D816V (GI50=320 nM), and FLT3-ITD (GI50=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive[1].
References	[1]. Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57(38):5576-5590.

Molecular Formula	C₃₅H₃₀N₄O₅
Molecular Weight	586.64

(R)-3-Hydroxy Midostaurin

Use of (R)-3-Hydroxy Midostaurin

Names

(R)-3-Hydroxy Midostaurin Biological Activity

Chemical & Physical Properties