pyrante

Modify Date: 2024-01-11 19:44:35

pyrante structure	Common Name	pyrante
	CAS Number	15686-83-6	Molecular Weight	594.67700
	Density	1.13g/cm3	Boiling Point	324.4ºC at 760mmHg
	Molecular Formula	C₃₄H₃₀N₂O₆S	Melting Point	178-179ºC
	MSDS	N/A	Flash Point	150ºC

Use of pyrante

Pyrantel is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis[1][2].

Name	pyrantel
Synonym	More Synonyms

Description	Pyrantel is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR
Target	Parasites[1][2].
In Vitro	Pyrantel (10 nM-10 µM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity[1][2]. Cell Viability Assay[1] Cell Line: A. suum Concentration: 10 nM-10 µM Incubation Time: 72 h Result: Inhibited A. suum with a pEC50 value of 7.24. Cell Viability Assay[2] Cell Line: N. americanus Concentration: 0-168.2 M (0-100 µg/mL) Incubation Time: 72 h Result: Inhibited third-stage larvae and adult of N. americanus with IC50 values of 2.0 and 7.6 mg/mL, respectively.
In Vivo	Pyrantel (10 mg/kg; p.o.; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%[2]. Animal Model: Male Syrian Golden hamsters (3-week-old; A. ceylanicum-infected)[2]. Dosage: 10 mg/kg Administration: Oral administration; single. Result: Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively.

Density	1.13g/cm3
Boiling Point	324.4ºC at 760mmHg
Melting Point	178-179ºC
Molecular Formula	C₃₄H₃₀N₂O₆S
Molecular Weight	594.67700
Flash Point	150ºC
Exact Mass	594.18200
PSA	158.90000
LogP	6.26020
Vapour Pressure	2.13E-17mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW0248000

CHEMICAL NAME :: Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)-, (E)-

CAS REGISTRY NUMBER :: 15686-83-6

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H14-N2-S

MOLECULAR WEIGHT :: 206.33

WISWESSER LINE NOTATION :: T6N CN AUTJ B1U1- BT5SJ& C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 175 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANBCB3 Antibiotics and Chemotherapy (Basel). (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.17- 1971- Volume(issue)/page/year: 30,1,1981

HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

pyrante

banminth

Pyrantel Base

1,4,5,6-Tetrahydro-1-methyl-2-[(E)-2-(2-thienyl)vinyl]pyrimidine

PYRANTEL PARMOATE

strongid

pyrequan

4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)-(e)-pyrimidin

1-methyl-2-(2-thiophen-2-ylvinyl)-1,4,5,6-tetrahydro-pyrimidine

PYRANTELUM

1-methyl-2-(trans-2-thiophen-2-yl-vinyl)-1,4,5,6-tetrahydro-pyrimidine

Henan Tianfu Chemical Co., Ltd.
China
Product Name: pyrante
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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pyrante

Use of pyrante

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pyrante Biological Activity

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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