Hemiasterlin
Modify Date: 2025-08-25 18:01:34
Hemiasterlin structure
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Common Name | Hemiasterlin | ||
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| CAS Number | 157207-90-4 | Molecular Weight | 526.71100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H46N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HemiasterlinHemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs)[1]. |
| Name | (E,4S)-4-[[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-(methylamino)-3-(1-methylindol-3-yl)butanoyl]amino]butanoyl]-methylamino]-2,5-dimethylhex-2-enoic acid |
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| Synonym | More Synonyms |
| Description | Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs)[1]. |
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| Related Catalog | |
| Target |
Pyrrolobenzodiazepines |
| In Vitro | Hemiasterlin is an antimitotic agent by disrupting microtubule dynamics causing mitotic arrest and cell death with low- to sub-nanomolar potencies against several cancer cell lines[1]. |
| References |
| Molecular Formula | C30H46N4O4 |
|---|---|
| Molecular Weight | 526.71100 |
| Exact Mass | 526.35200 |
| PSA | 107.16000 |
| LogP | 5.31990 |
| Milnamide B |
| UNII-6S0T7U2I3F |
| Hemiasterlin |