1,4-PBIT DIHYDROBROMIDE

Modify Date: 2024-01-18 17:53:16

1,4-PBIT DIHYDROBROMIDE structure	Common Name	1,4-PBIT DIHYDROBROMIDE
	CAS Number	157254-60-9	Molecular Weight	444.25
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₂₀Br₂N₄S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 1,4-PBIT DIHYDROBROMIDE

1,4-PBIT (1,4-PB-ITU) dihydrobromide (compound 46) is a potent nitric oxide synthases (NOS) inhibitor, with Ki values of 7.6 nM, 360 nM, and 16 nM for the inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) isozymes, respectively[1].

Name	2-[4-(2-carbamimidoylsulfanylethyl)phenyl]ethyl carbamimidothioate,dihydrobromide
Synonym	More Synonyms

Description	1,4-PBIT (1,4-PB-ITU) dihydrobromide (compound 46) is a potent nitric oxide synthases (NOS) inhibitor, with Ki values of 7.6 nM, 360 nM, and 16 nM for the inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) isozymes, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Target	iNOS:7.6 nM (Ki) eNOS:360 nM (Ki) nNOS:16 nM (Ki)
References	[1]. E P Garvey, et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem. 1994 Oct 28;269(43):26669-76.