NSC363998 free base
Modify Date: 2025-12-19 11:39:05
NSC363998 free base structure
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Common Name | NSC363998 free base | ||
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| CAS Number | 159357-82-1 | Molecular Weight | 440.54 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H32N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NSC363998 free baseNSC363998 (free base) is an orally active compound. NSC363998 (free base) can suppress rCGG90 induced neurotoxicity. NSC363998 (free base) can be used for the research of neurodegenerative disorder such as Fragile X associated tremor/ataxia syndrome (FXTAS)[1]. |
| Name | NSC363998 free base |
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| Description | NSC363998 (free base) is an orally active compound. NSC363998 (free base) can suppress rCGG90 induced neurotoxicity. NSC363998 (free base) can be used for the research of neurodegenerative disorder such as Fragile X associated tremor/ataxia syndrome (FXTAS)[1]. |
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| Related Catalog | |
| In Vivo | NSC363998 (free base) (oral; 0, 5 μM) can suppress rCGG90 induced neurotoxicity[1]. Animal Model: FXTAS Drosophila model[1] Dosage: 0, 5 μM Administration: Oral (dissolved in DMSO and added to standard food) Result: Could modify ommatidial degeneration and diminished neddylation activity in the FXTAS Drosophila model. |
| References |
| Molecular Formula | C24H32N4O4 |
|---|---|
| Molecular Weight | 440.54 |
| InChIKey | ZDFMCUHFIYMYTO-UHFFFAOYSA-N |
| SMILES | O=C1c2cccc(NCCCNCCO)c2C(=O)c2cccc(NCCCNCCO)c21 |
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: Single Concentration Validation of Csn-Mediated Deneddylation of Cullin-Ring Ligase U...
Source: Burnham Center for Chemical Genomics
Target: COP9 signalosome complex subunit 5 [Homo sapiens]
External Id: SBCCG-A995-CSN5-CP-Assay
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Name: Single concentration validation of Csn-Mediated Deneddylation of Cullin-Ring Ligase H...
Source: Burnham Center for Chemical Genomics
Target: 72 kDa type IV collagenase isoform a preproprotein [Homo sapiens]
External Id: SBCCG-A996-CSN5-MMP2-CP-Assay
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
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Name: Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Lum...
Source: The Scripps Research Institute Molecular Screening Center
Target: transactivating tegument protein VP16 [Human herpesvirus 1]
External Id: VP16_INH_LUMI_1536_3X%INH CSRUN for SRC1
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Name: Single concentration validation of Csn-Mediated Deneddylation of Cullin-Ring Ligase U...
Source: Burnham Center for Chemical Genomics
Target: TPA: prothrombin [Bos taurus]
External Id: SBCCG-A997-CSN5-thrombin-CP-Assay
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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