ABT-089
Modify Date: 2025-08-22 21:20:47
ABT-089 structure
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Common Name | ABT-089 | ||
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| CAS Number | 161417-03-4 | Molecular Weight | 192.25800 | |
| Density | 1.046g/cm3 | Boiling Point | 302.7ºC at 760mmHg | |
| Molecular Formula | C11H16N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 136.9ºC | |
Use of ABT-089Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM.Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction[1]. |
| Name | 2-Methyl-3-[(2S)-2-pyrrolidinylmethoxy]pyridine |
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| Description | Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM.Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction[1]. |
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| Related Catalog | |
| Target |
Ki: 16 nM (α4β2* nAChR)[1] |
| References |
| Density | 1.046g/cm3 |
|---|---|
| Boiling Point | 302.7ºC at 760mmHg |
| Molecular Formula | C11H16N2O |
| Molecular Weight | 192.25800 |
| Flash Point | 136.9ºC |
| Exact Mass | 192.12600 |
| PSA | 34.15000 |
| LogP | 1.84960 |
| Vapour Pressure | 0.000975mmHg at 25°C |
| Index of Refraction | 1.517 |