Acivicin hydrochloride
Modify Date: 2025-08-27 07:39:16
Acivicin hydrochloride structure
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Common Name | Acivicin hydrochloride | ||
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| CAS Number | 161922-40-3 | Molecular Weight | 215.03 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C5H8Cl2N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Acivicin hydrochlorideAcivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ−glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2]. |
| Name | Acivicin hydrochloride |
|---|
| Description | Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ−glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2]. |
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| Related Catalog | |
| Target |
γ−glutamyl transpeptidase[1] |
| In Vitro | Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days) has an IC50 of 0.7 μM in human HepG2 cells[1]. |
| In Vivo | Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days; for 4 days) reduces urinary gamma-GT by 70-78%[1]. Animal Model: Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene[1] Dosage: 5 mg/kg Administration: IP; twice weekly (monday and wednesday); for 4 days Result: Reduced urinary gamma-GT by 70-78%. |
| References |
| Molecular Formula | C5H8Cl2N2O3 |
|---|---|
| Molecular Weight | 215.03 |