THZ1-R structure
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Common Name | THZ1-R | ||
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CAS Number | 1621523-07-6 | Molecular Weight | 568.069 | |
Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
Molecular Formula | C31H30ClN7O2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of THZ1-RTHZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM. |
Name | THZ1-R |
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Synonym | More Synonyms |
Description | THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM. |
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Related Catalog | |
Target |
CDK7:146 nM (IC50) |
In Vitro | THZ1-R shows lower affinity at CDK7 than THZ1, with IC50 of 146 nM[1]. |
Cell Assay | Cells are seeded in 384-well microplates at 15% confluency in medium with 5% FBS and penicillin/streptavidin. Cells are treated with THZ1 or DMSO for 72 hrs and cell viability is determined using resazurin. |
References |
Density | 1.4±0.1 g/cm3 |
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Molecular Formula | C31H30ClN7O2 |
Molecular Weight | 568.069 |
Exact Mass | 567.214966 |
LogP | 4.70 |
Index of Refraction | 1.720 |
Storage condition | 2-8℃ |
Benzamide, N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-4-[[4-(dimethylamino)-1-oxobutyl]amino]- |
N-(3-{[5-Chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino}phenyl)-4-{[4-(dimethylamino)butanoyl]amino}benzamide |