cis CM-414
Modify Date: 2024-04-02 18:15:23
cis CM-414 structure
|
Common Name | cis CM-414 | ||
|---|---|---|---|---|
| CAS Number | 1624792-70-6 | Molecular Weight | 439.516 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H29N5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of cis CM-414A first-in-class, dual inhibitor of PDE5 and HDAC that inhibits HDAC1/2/3/6 (IC50=310/490/322/91 nM, respectively) and PDE5 (IC50=60 nM); does not inhibit class IIa HDAC isoforms, MMP-3, MMP-10, and PDE9 (IC50>10 uM), has modest or weak activity for HDAC8/11/10 (IC50=640/550/2400 nM); diminishes brain Aβ and pTau levels, increases the inactive form of GSK3β, reverts the decrease in dendritic spine density on hippocampal neurons, and reverses the cognitive deficits in Tg2576 mice. |
| Name | cis CM-414 |
|---|
| Description | A first-in-class, dual inhibitor of PDE5 and HDAC that inhibits HDAC1/2/3/6 (IC50=310/490/322/91 nM, respectively) and PDE5 (IC50=60 nM); does not inhibit class IIa HDAC isoforms, MMP-3, MMP-10, and PDE9 (IC50>10 uM), has modest or weak activity for HDAC8/11/10 (IC50=640/550/2400 nM); diminishes brain Aβ and pTau levels, increases the inactive form of GSK3β, reverts the decrease in dendritic spine density on hippocampal neurons, and reverses the cognitive deficits in Tg2576 mice. |
|---|---|
| References | References 1. Cuadrado-Tejedor M, et al. Neuropsychopharmacology. 2017 Jan;42(2):524-539. View Related Products by Target HDAC |
| Molecular Formula | C23H29N5O4 |
|---|---|
| Molecular Weight | 439.516 |