AF 64394

Modify Date: 2024-01-05 08:36:18

Use of AF 64394

AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.

Name	AF64394
Synonym	More Synonyms

Description	AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
Target	pIC50: 7.3 (GPR3)[1].
In Vitro	AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3. AF34394 and related compounds are only of modest potency and are relatively lipophilic (e.g., AF34394 clogP=5.2, LLE=2.1, and 14b clog P=3.1 and LLE=3.2) the series shows promising SAR and represents an excellent start point for further optimization[1].
References	[1]. Jensen T, et al. The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5195-8.

N-(4-Chloro-2-isopropoxybenzyl)-5-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, N-[[4-chloro-2-(1-methylethoxy)phenyl]methyl]-5-phenyl-

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Price: ￥1980/10 mM * 1 mL in DMSO

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