AM-0466
Modify Date: 2024-01-06 08:16:27
AM-0466 structure
|
Common Name | AM-0466 | ||
|---|---|---|---|---|
| CAS Number | 1642113-59-4 | Molecular Weight | 552.524 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 747.2±70.0 °C at 760 mmHg | |
| Molecular Formula | C27H19F3N4O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 405.7±35.7 °C | |
Use of AM-0466AM-0466 is a potent and selective NaV1.7 Inhibitor (Nav 1.7 IC50 = 21 nM; Nav 1.5 IC50 =>30.0 uM. PXR = 22% @10 uM; CYP 2C9 IC50 = 4.6 uM; CYP3A4 TDI IC50 =>50.0 uM.). |
| Name | 1-[3-Methoxy-3'-(trifluoromethyl)-4-biphenylyl]-2-oxo-N-(2-pyrimidinyl)-1,2-dihydro-6-quinolinesulfonamide |
|---|---|
| Synonym | More Synonyms |
| Description | AM-0466 is a potent and selective NaV1.7 Inhibitor (Nav 1.7 IC50 = 21 nM; Nav 1.5 IC50 =>30.0 uM. PXR = 22% @10 uM; CYP 2C9 IC50 = 4.6 uM; CYP3A4 TDI IC50 =>50.0 uM.). |
|---|---|
| In Vitro | AM-0466 is a potent and selective NaV1.7 Inhibitor (Nav 1.7 IC50 = 21 nM; Nav 1.5 IC50 =>30.0 uM. PXR = 22% @10 uM; CYP 2C9 IC50 = 4.6 uM; CYP3A4 TDI IC50 =>50.0 uM.). AM-0466 Affords Robust in Vivo Activity. AM-0466 demonstrated robust pharmacodynamic activity in a NaV1.7-dependent model of histamine-induced pruritus (itch) and additionally in a capsaicin-induced nociception model of pain without any confounding effect in open-field activity. |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 747.2±70.0 °C at 760 mmHg |
| Molecular Formula | C27H19F3N4O4S |
| Molecular Weight | 552.524 |
| Flash Point | 405.7±35.7 °C |
| Exact Mass | 552.107910 |
| LogP | 4.42 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.636 |
| 1-[3-Methoxy-3'-(trifluoromethyl)-4-biphenylyl]-2-oxo-N-(2-pyrimidinyl)-1,2-dihydro-6-quinolinesulfonamide |
| 6-Quinolinesulfonamide, 1,2-dihydro-1-[3-methoxy-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-2-oxo-N-2-pyrimidinyl- |