(Rac)-Tavapadon

Modify Date: 2024-01-10 21:44:56

(Rac)-Tavapadon Structure
(Rac)-Tavapadon structure
Common Name (Rac)-Tavapadon
CAS Number 1643462-64-9 Molecular Weight 391.34
Density N/A Boiling Point N/A
Molecular Formula C19H16F3N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (Rac)-Tavapadon


(Rac)-Tavapadon ((Rac)-PF-06649751; (Rac)-CVL-751) is a potent and selective noncatechol dopamine D1 receptor agonist. (Rac)-Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the β-arrestin2 recruitment assay (GS-cAMP, EC50=0.8 nM; β-arrestin2, EC50=68 nM). (Rac)-Tavapadon has antiparkinsonian activity[1].

 Names

Name (Rac)-Tavapadon

 (Rac)-Tavapadon Biological Activity

Description (Rac)-Tavapadon ((Rac)-PF-06649751; (Rac)-CVL-751) is a potent and selective noncatechol dopamine D1 receptor agonist. (Rac)-Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the β-arrestin2 recruitment assay (GS-cAMP, EC50=0.8 nM; β-arrestin2, EC50=68 nM). (Rac)-Tavapadon has antiparkinsonian activity[1].
Related Catalog
Target

D1 Receptor

In Vitro (Rac)-Tavapadon ((Rac)-PF-06649751; (Rac)-CVL-751; compound 32) has EMAXs of 118% and 30% in the GS activation assay and the β-arrestin2 recruitment assay[1].
References

[1]. Michael L Martini, et al. Designing Functionally Selective Noncatechol Dopamine D 1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity. ACS Chem Neurosci. 2019 Sep 18;10(9):4160-4182.

 Chemical & Physical Properties

Molecular Formula C19H16F3N3O3
Molecular Weight 391.34