N-Boc-dolaproine-methyl

Modify Date: 2024-04-02 15:10:44

N-Boc-dolaproine-methyl Structure
N-Boc-dolaproine-methyl structure
Common Name N-Boc-dolaproine-methyl
CAS Number 164456-57-9 Molecular Weight 287.35200
Density N/A Boiling Point N/A
Molecular Formula C14H25NO5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of N-Boc-dolaproine-methyl


N-Boc-dolaproine-methyl is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity[1].

 Names

Name (S)-tert-butyl 2-((1R,2R)-1-hydroxy-3-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate

 N-Boc-dolaproine-methyl Biological Activity

Description N-Boc-dolaproine-methyl is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity[1].
Related Catalog
References

[1]. Almeida W P, et al. An easy and stereoselective synthesis of N-Boc-dolaproine via the Baylis–Hillman reaction[J]. Tetrahedron letters, 2003, 44(5): 937-940.

 Chemical & Physical Properties

Molecular Formula C14H25NO5
Molecular Weight 287.35200
Exact Mass 287.17300
PSA 76.07000
LogP 1.49380
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