(R)-9b
Modify Date: 2025-08-25 11:47:14
(R)-9b structure
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Common Name | (R)-9b | ||
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| CAS Number | 1655527-68-6 | Molecular Weight | 499.027 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H27ClN6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (R)-9bAck1 inhibitor (R)-9b is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM; also inhibits JAK2 (IC50=6 nM) and Tyk2 (IC50=5 nM), 3-fold selectvity over ALK and 10-fold over c-Src; potently suppresses proliferation of human cancer cell lines with IC50 <2 uM; exhibits considerable stability in human plasma and a long half-life. |
| Name | 4-{4-[(5-Chloro-4-{[(2R)-tetrahydro-2-furanylmethyl]amino}-2-pyrimidinyl)amino]phenyl}-1-methylpiperazin-1-ium methanesulfonate |
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| Synonym | More Synonyms |
| Description | Ack1 inhibitor (R)-9b is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM; also inhibits JAK2 (IC50=6 nM) and Tyk2 (IC50=5 nM), 3-fold selectvity over ALK and 10-fold over c-Src; potently suppresses proliferation of human cancer cell lines with IC50 <2 uM; exhibits considerable stability in human plasma and a long half-life. |
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| References | References 1. Mahajan K, et al. Cancer Cell. 2017 Jun 12;31(6):790-803.e8. 2. Wu X, et al. Oncotarget. 2017 Jan 10;8(2):2971-2983. 3. Lawrence HR, et al. J Med Chem. 2015 Mar 26;58(6):2746-63. View Related Products by Target Ack1 (TNK2) |
| Molecular Formula | C20H27ClN6O |
|---|---|
| Molecular Weight | 499.027 |
| Exact Mass | 498.181610 |
| 4-{4-[(5-Chloro-4-{[(2R)-tetrahydro-2-furanylmethyl]amino}-2-pyrimidinyl)amino]phenyl}-1-methylpiperazin-1-ium methanesulfonate |
| Piperazinium, 4-[4-[[5-chloro-4-[[[(2R)-tetrahydro-2-furanyl]methyl]amino]-2-pyrimidinyl]amino]phenyl]-1-methyl- methanesulfonate (1:1) |