(S)-(-)-Stepholidine

Modify Date: 2025-08-26 10:08:29

(S)-(-)-Stepholidine structure	Common Name	(S)-(-)-Stepholidine
	CAS Number	16562-13-3	Molecular Weight	327.374
	Density	1.4±0.1 g/cm3	Boiling Point	524.0±50.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₂₁NO₄	Melting Point	120-122ºC
	MSDS	N/A	Flash Point	270.7±30.1 °C

Use of (S)-(-)-Stepholidine

L-Stepholidine (Stepholidine), an alkaloid extract of the Chinese herb Stephania intermedia, is the first compound known to exhibit mixed dopamine D1 receptor agonist/D2 antagonist properties. L-Stepholidine (Stepholidine) has neuroprotective effect and inhibits heroin-induced reinstatement. L-Stepholidine (Stepholidine) is a potential medication for the treatment of opiate addiction[1][2][3].

Name	L-Stepholidine
Synonym	More Synonyms

Description	L-Stepholidine (Stepholidine), an alkaloid extract of the Chinese herb Stephania intermedia, is the first compound known to exhibit mixed dopamine D1 receptor agonist/D2 antagonist properties. L-Stepholidine (Stepholidine) has neuroprotective effect and inhibits heroin-induced reinstatement. L-Stepholidine (Stepholidine) is a potential medication for the treatment of opiate addiction[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	Dopamine D1 receptor[1] Dopamine D2 receptor[1]
References	[1]. Ma B, et al. L-stepholidine, a natural dopamine receptor D1 agonist and D2 antagonist, inhibits heroin-induced reinstatement. Neurosci Lett. 2014 Jan 24;559:67-71. [2]. Zhou M, et al. The Neuroprotective Effect of L-Stepholidine on Methamphetamine-Induced Memory Deficits in Mice. Neurotox Res. 2019 Aug;36(2):376-386. [3]. Wang W, et al. The effect of L-stepholidine, a novel extract of Chinese herb, on the acquisition, expression, maintenance, and re-acquisition of morphine conditioned place preference in rats. Neuropharmacology. 2007 Feb;52(2):355-61. Epub 2006 Oct 5.

Density	1.4±0.1 g/cm3
Boiling Point	524.0±50.0 °C at 760 mmHg
Melting Point	120-122ºC
Molecular Formula	C₁₉H₂₁NO₄
Molecular Weight	327.374
Flash Point	270.7±30.1 °C
Exact Mass	327.147064
PSA	62.16000
LogP	2.16
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.680

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DR9823500

CHEMICAL NAME :: 13a-alpha-Berbine-2,10-diol, 3,9-dimethoxy-

CAS REGISTRY NUMBER :: 16562-13-3

LAST UPDATED :: 198707

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H21-N-O4

MOLECULAR WEIGHT :: 327.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 928 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 6,156,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 358 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,522,1986

HS Code	2933990090

N/A

CAS#:1196996-62-9

3,9-Dimethoxy-5...

CAS#:16562-14-4

(S)-(-)-Stepholidine

CAS#:16562-13-3

Literature: Journal of Organic Chemistry, , vol. 74, # 23 p. 9225 - 9228

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(13aS)-3,9-Dimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline-2,10-diol

(13aS)-3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol

(-)-Stepholidine

6H-Dibenzo[a,g]quinolizine-2,10-diol, 5,8,13,13a-tetrahydro-3,9-dimethoxy-, (13aS)-

(S)-3,9-Dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,10-diol

(13aS)-3,9-Dimethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-2,10-diol

L-Stepholidine

Stepholidine

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (S)-(-)-Stepholidine
Price: Check
Purity: 98.0%
Delivery: 10 Day
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (S)-(-)-Stepholidine
Price: ￥1148.0/10mg
Purity: 98.0%
Delivery: 1 Day
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Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: L-Stepholidine
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: L-Stepholidine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: L-Stepholidine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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(S)-(-)-Stepholidine

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