8-(3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

Modify Date: 2026-08-02 21:12:12

8-(3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one structure	Common Name	8-(3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
	CAS Number	1661839-48-0	Molecular Weight	395.9
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₂ClN₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Name	8-(3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

Molecular Formula	C₂₁H₂₂ClN₅O
Molecular Weight	395.9
InChIKey	VIEYRTKHMAJVMI-UHFFFAOYSA-N
SMILES	Cn1ncc2cc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)ccc21

Name: Inhibition of CDK8 (unknown origin) at 200 nM incubated in presence of ATP by ADP-Glo...
Source: ChEMBL
Target: Cyclin-dependent kinase 8
External Id: CHEMBL5119580

Name: Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibi...
Source: ChEMBL
Target: HCT-116
External Id: CHEMBL5119581

Name: Selectivity ratio of GI50 for antiproliferative activity against human HCT-116 cells ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5119702

Name: Selectivity ratio of GI50 for antiproliferative activity against human HT-29 cells to...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5119703

Name: Selectivity ratio of GI50 for antiproliferative activity against human SW480 cells to...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5119704

Name: Selectivity ratio of GI50 for antiproliferative activity against mouse CT26 cells to ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5119705

Name: Inhibition of WNT signaling in human 7dF3 cells preincubated for 2 hrs before beta-es...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3413185

Name: Intrinsic clearance in mouse liver microsome at 1 uM preincubated for 5 mins by LC-MS...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3413195

Name: Intrinsic clearance in rat liver microsome at 1 uM preincubated for 5 mins by LC-MS a...
Source: ChEMBL
Target: Liver microsome
External Id: CHEMBL3413196

Name: Intrinsic clearance in human liver microsome at 1 uM preincubated for 5 mins by LC-MS...
Source: ChEMBL
Target: Liver microsome
External Id: CHEMBL3413197

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8-(3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

Names

Chemical & Physical Properties

Bioassay

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.