19H-2,3,7-[1,3]Butadien[1]yl[4]ylidene-9,12-etheno-14,18-metheno-4H-pyrido[2,3,4-tu]-1,13,6-benzodioxaazacyclodocosine,5,6,7,8,19a,20,21,22-octahydro-15,24,25,31,32-pentamethoxy-6,20-dimethyl-,(7S,19a

Modify Date: 2024-01-08 10:35:25

19H-2,3,7-[1,3]Butadien[1]yl[4]ylidene-9,12-etheno-14,18-metheno-4H-pyrido[2,3,4-tu]-1,13,6-benzodioxaazacyclodocosine,5,6,7,8,19a,20,21,22-octahydro-15,24,25,31,32-pentamethoxy-6,20-dimethyl-,(7S,19a Structure
19H-2,3,7-[1,3]Butadien[1]yl[4]ylidene-9,12-etheno-14,18-metheno-4H-pyrido[2,3,4-tu]-1,13,6-benzodioxaazacyclodocosine,5,6,7,8,19a,20,21,22-octahydro-15,24,25,31,32-pentamethoxy-6,20-dimethyl-,(7S,19a structure
Common Name 19H-2,3,7-[1,3]Butadien[1]yl[4]ylidene-9,12-etheno-14,18-metheno-4H-pyrido[2,3,4-tu]-1,13,6-benzodioxaazacyclodocosine,5,6,7,8,19a,20,21,22-octahydro-15,24,25,31,32-pentamethoxy-6,20-dimethyl-,(7S,19a
CAS Number 16623-56-6 Molecular Weight 652.77600
Density 1.175g/cm3 Boiling Point 739.9ºC at 760mmHg
Molecular Formula C39H44N2O7 Melting Point N/A
MSDS N/A Flash Point 181.1ºC

 Names

Name Thalidasine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.175g/cm3
Boiling Point 739.9ºC at 760mmHg
Molecular Formula C39H44N2O7
Molecular Weight 652.77600
Flash Point 181.1ºC
Exact Mass 652.31500
PSA 71.09000
LogP 7.04680
Vapour Pressure 9.29E-22mmHg at 25°C
Index of Refraction 1.58

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XG2005000
CHEMICAL NAME :
Thalidasine
CAS REGISTRY NUMBER :
16623-56-6
LAST UPDATED :
199412
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C39-H44-N2-O7
MOLECULAR WEIGHT :
652.85

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
520 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 11,217,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 15(7),46,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2100 mg/kg/7D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Related to Chronic Data - death
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 11,217,1980

 Synonyms

O-methyl-thalfoetidine
O-Methylthalfetidine
6,6',7,7',12-Pentamethoxy-2,2'-dimethylthalidasan
Thalidasin
O-Methylthalfoetidin
O-methyl-thalrugosidine
Thalidusine,(S,S)
6,7,12,6',7'-pentamethoxy-2,2'-dimethyl-thalidasane