Tenofovir diphosphate
Modify Date: 2025-08-27 09:14:20
Tenofovir diphosphate structure
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Common Name | Tenofovir diphosphate | ||
|---|---|---|---|---|
| CAS Number | 166403-66-3 | Molecular Weight | 447.17200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C9H16N5O10P3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Tenofovir diphosphateTenofovir diphosphate (TFV-DP) is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT)[1]. |
| Name | [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Tenofovir diphosphate (TFV-DP) is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT)[1]. |
|---|---|
| Related Catalog | |
| Target |
DNA polymerases; HIV-1 reverse transcriptase[1] |
| In Vitro | Tenofovir diphosphate acts as an inhibitor of DNA pol. Tenofovir-diphosphate is a weak inhibitor of DNA polymerases (pol) α, δ, and ɛ, with values for the Ki for PMPApp (PMPAppKi) relative to the Km for dATP (dATPKm) of 10.2, 10.2, and 15.6, respectively[1]. |
| References |
| Molecular Formula | C9H16N5O10P3 |
|---|---|
| Molecular Weight | 447.17200 |
| Exact Mass | 447.01100 |
| PSA | 258.87000 |
| LogP | 0.76400 |
| InChIKey | IACQCQDWSIQSRP-ZCFIWIBFSA-N |
| SMILES | CC(Cn1cnc2c(N)ncnc21)OCP(=O)(O)OP(=O)(O)OP(=O)(O)O |
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Name: Activity at HIV1 reverse transcriptase measured after 30 mins
Source: ChEMBL
Target: Reverse transcriptase/RNaseH
External Id: CHEMBL1675307
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Name: Binding affinity to HIV1 reverse transcriptase
Source: ChEMBL
Target: Reverse transcriptase/RNaseH
External Id: CHEMBL1675423
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Name: Ratio of Kpol to Kd for HIV1 reverse transcriptase
Source: ChEMBL
Target: Reverse transcriptase/RNaseH
External Id: CHEMBL1675424
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Name: Selectivity, ratio of Kpol to Kd for dATP to Kpol to Kd for compound at HIV1 reverse ...
Source: ChEMBL
Target: Reverse transcriptase/RNaseH
External Id: CHEMBL1675425
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Name: Substrate activity at human DNA polymerase gamma assessed as elongation of primer at ...
Source: ChEMBL
Target: DNA polymerase subunit gamma-1
External Id: CHEMBL5518618
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Name: Substrate activity at human DNA polymerase gamma assessed as elongation of primer at ...
Source: ChEMBL
Target: DNA polymerase subunit gamma-1
External Id: CHEMBL5518617
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Name: Substrate activity at HIV reverse transcriptase assessed as n+1 band formation at 97....
Source: ChEMBL
Target: N/A
External Id: CHEMBL5518614
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Name: Substrate activity at HIV reverse transcriptase assessed as elongation of primer at 9...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5518613
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| tenofovir diphosphate |
| TNV |
| PMPApp |
| PMPA diphosphate |
| TFVTP |
| Tenofovir-DP |
| [2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY]METHYL-TRIPHOSPHATE |