TGP-377/421

Modify Date: 2025-09-23 12:01:29

TGP-377/421 Structure
TGP-377/421 structure
 Common Name TGP-377/421
CAS Number 16752-89-9 Molecular Weight 340.39
Density N/A Boiling Point N/A
Molecular Formula C20H16N6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TGP-377/421


TGP-377/421 (Targapre-miR-377/421) is a smalll molecule targets pre-miR-377 and inhibits its processing, binds to miR-377's Dicer processing site with Kd of 29 uM.TGP-377/421 inhibits the cellular biogenesis of miR-377 in HUVECs, reduced mature miR-377 levels in a dose-dependent fashion with IC50 of 5 uM, also inhibits miR-421.

 Names

Name TGP-377/421

 TGP-377/421 Biological Activity

Description TGP-377/421 (Targapre-miR-377/421) is a smalll molecule targets pre-miR-377 and inhibits its processing, binds to miR-377's Dicer processing site with Kd of 29 uM.TGP-377/421 inhibits the cellular biogenesis of miR-377 in HUVECs, reduced mature miR-377 levels in a dose-dependent fashion with IC50 of 5 uM, also inhibits miR-421.
References 1. Hafeez S Haniff, et al. Nat Chem. 2020 Oct;12(10):952-961.

 Chemical & Physical Properties

Molecular Formula C20H16N6
Molecular Weight 340.39
InChIKey AQEJANNNADGRSY-UHFFFAOYSA-N
SMILES Nc1ccc2nc(-c3cccc(-c4nc5ccc(N)cc5[nH]4)c3)[nH]c2c1
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Chemsrc provides TGP-377/421(CAS#:16752-89-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of TGP-377/421 are included as well.>> amp version: TGP-377/421

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