FR179642

Modify Date: 2024-01-05 17:02:56

FR179642 Structure
FR179642 structure
Common Name FR179642
CAS Number 168110-44-9 Molecular Weight 936.894
Density 1.8±0.1 g/cm3 Boiling Point N/A
Molecular Formula C35H52N8O20S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FR179642


FR179642 is a key intermediate in the synthesis of the echinocandin antifungal Micafungin[1]. FR179642 is the cyclic peptide nucleus of the echinocandin-like antifungal lipopeptide FR901379[2].

 Names

Name fr179642
Synonym More Synonyms

 FR179642 Biological Activity

Description FR179642 is a key intermediate in the synthesis of the echinocandin antifungal Micafungin[1]. FR179642 is the cyclic peptide nucleus of the echinocandin-like antifungal lipopeptide FR901379[2].
Related Catalog
References

[1]. Satoshi Ueda, et al. Cloning and expression of the FR901379 acylase gene from Streptomyces sp. no. 6907. J Antibiot (Tokyo)

[2]. M Tomishima, et al. FK463, a novel water-soluble echinocandin lipopeptide: synthesis and antifungal activity. J Antibiot (Tokyo)

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Molecular Formula C35H52N8O20S
Molecular Weight 936.894
Exact Mass 936.301880
PSA 480.18000
LogP -12.95
Index of Refraction 1.718

 Synonyms

5-[(1S,2S)-2-{(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-Amino-20-[(1R)-3-amino-1-hydroxy-3-oxopropyl]-2,11,12,15-tetrahydroxy-6-[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl}-1,2-dihydroxyethyl]-2-hydroxyphenyl hydrogen sulfate
Micafungin FR-179642
1H-Dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacycloheneicosine-20-propanamide, 9-amino-23-[(1S,2S)-1,2-dihydroxy-2-[4-hydroxy-3-(sulfooxy)phenyl]ethyl]tetracosahydro-β,2,11,12,15-pentahydroxy-6 -[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxo-, (βR,2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-
FR-179642
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