Nifursol

Modify Date: 2024-01-02 22:57:38

Nifursol Structure
Nifursol structure
Common Name Nifursol
CAS Number 16915-70-1 Molecular Weight 365.21200
Density 1.87 g/cm3 Boiling Point N/A
Molecular Formula C12H7N5O9 Melting Point 215-220ºC (dec.)
MSDS N/A Flash Point N/A

 Use of Nifursol


Nifursol is a nitrofuran antibiotic which inhibits the growth of Histomonas meleagridis but is not lethal to the flagellated protozoan. Target: AntibacterialNifursol can be analyzed and detected in tissues using intact 3,5-dinitrosalicylic acid hydrazide side chains along with electron-capture GC, spectrophotometric detection, and HPLC with ultraviolet light detection. In tissues, it has been observed that Nifursol is tightly bound to proteins and requires basic solutions such as ammonia to break the bonds between the two.

 Names

Name 2-hydroxy-3,5-dinitro-N-[(E)-(5-nitrofuran-2-yl)methylideneamino]benzamide
Synonym More Synonyms

 Nifursol Biological Activity

Description Nifursol is a nitrofuran antibiotic which inhibits the growth of Histomonas meleagridis but is not lethal to the flagellated protozoan. Target: AntibacterialNifursol can be analyzed and detected in tissues using intact 3,5-dinitrosalicylic acid hydrazide side chains along with electron-capture GC, spectrophotometric detection, and HPLC with ultraviolet light detection. In tissues, it has been observed that Nifursol is tightly bound to proteins and requires basic solutions such as ammonia to break the bonds between the two.
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 Chemical & Physical Properties

Density 1.87 g/cm3
Melting Point 215-220ºC (dec.)
Molecular Formula C12H7N5O9
Molecular Weight 365.21200
Exact Mass 365.02400
PSA 212.29000
LogP 3.43420
Index of Refraction 1.742
Storage condition Refrigerator, Under Inert Atmosphere

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VO2980000
CHEMICAL NAME :
Salicylic acid, 3,5-dinitro-(5-nitrofurfurylidene)hydrazide
CAS REGISTRY NUMBER :
16915-70-1
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C12-H7-N5-O9
MOLECULAR WEIGHT :
365.24
WISWESSER LINE NOTATION :
T5OJ BNW E1UNMVR BQ CNW ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 12,371,1969
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 12,371,1969

 Safety Information

HS Code 2942000000

 Customs

HS Code 2932190090
Summary 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 Synonyms

MFCD00377430
Salfuride
NIFURSOL
Nifursolum [INN-Latin]
Histomon
EINECS 240-963-6
Nifursolo [DCIT]
Sulfuride