MTPG
MTPG structure
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Common Name | MTPG | ||
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| CAS Number | 169209-66-9 | Molecular Weight | 233.23 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H11N5O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of MTPGMTPG is a potent mGluR2 and mGluR3 antagonist. MTPG can block the induction of brain ischemic tolerance induced by cerebral ischemic preconditioning. MTPG also significantly attenuates the inhibitory effect of L-CCG-1 on the KCl-evoked dopamine release[1]. |
| Name | (±)-α-Methyl-(4-tetrazolylphenyl)glycine |
|---|---|
| Synonym | More Synonyms |
| Description | MTPG is a potent mGluR2 and mGluR3 antagonist. MTPG can block the induction of brain ischemic tolerance induced by cerebral ischemic preconditioning. MTPG also significantly attenuates the inhibitory effect of L-CCG-1 on the KCl-evoked dopamine release[1]. |
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| Related Catalog | |
| Target |
mGluR2, mGluR 3[1] |
| References |
[2]. Feng RF, Li WB, Liu HQ, et al. Sheng Li Xue Bao. 2003;55(3):303-310. |
| Molecular Formula | C10H11N5O2 |
|---|---|
| Molecular Weight | 233.23 |
| Exact Mass | 233.09100 |
| PSA | 106.92000 |
| LogP | 0.62110 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord.
Neuropharmacology 34 , 851-856, (1995) The depression of the monosynaptic excitation of neonatal rat motoneurones produced by the metabotropic glutamate receptor (mGluR) agonists (1S,3S)-1-aminocyclopentane-1, 3-dicarboxylate (ACPD) or L-2... |
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[Effects of alpha-methyl-(4-tetrazolyl-phenyl) glycine on the induction of hippocampal ischemic tolerance in the rat].
Sheng Li Xue Bao 55 , 303-10, (2003) To explore the role of metabotropic glutamate receptor 2/3 mGluR 2/3 in the induction of brain ischemic tolerance (BIT), the influences of mGluR2/3 antagonist alpha-methyl-(4-tetrazolyl-phenyl) glycin... |
| MFCD00672653 |
| 2-amino-2-[4-(tetrazol-1-yl)phenyl]propanoic acid |