Zapalog

Modify Date: 2025-09-20 17:54:58

Zapalog Structure
Zapalog structure
Common Name Zapalog
CAS Number 1708091-24-0 Molecular Weight 1108.24
Density N/A Boiling Point N/A
Molecular Formula C58H73N7O15 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Zapalog


Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis[1].

 Names

Name Zapalog

 Zapalog Biological Activity

Description Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis[1].
Related Catalog
References

[1]. Gutnick A, et al. The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria. Nat Cell Biol. 2019 Jun;21(6):768-777.

 Chemical & Physical Properties

Molecular Formula C58H73N7O15
Molecular Weight 1108.24
InChIKey ONSMHWXTRWDIMR-SXIGHEGWSA-N
SMILES CCC(C)(C)C(=O)C(=O)N1CCCCC1C(=O)OC(CCc1ccc(OC)c(OC)c1)c1cccc(NC(=O)CCCOc2cc([N+](=O)[O-])c(C(C)OCCOc3c(OC)cc(Cc4cnc(N)nc4N)cc3OC)cc2OC)c1
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