5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine

Modify Date: 2024-03-07 03:21:47

5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine Structure
5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine structure
Common Name 5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine
CAS Number 171486-53-6 Molecular Weight 693.74
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C38H39N5O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine


5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

 Names

Name 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-N-isobutyryl-2'-O-2-propyn-1-ylguanosine
Synonym More Synonyms

  Biological Activity

Description 5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Related Catalog
References

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C38H39N5O8
Molecular Weight 693.74
Exact Mass 693.279846
LogP 7.66
Index of Refraction 1.631

 Synonyms

Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-2'-O-2-propyn-1-yl-
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-N-isobutyryl-2'-O-2-propyn-1-ylguanosine
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