Dicarbine

Modify Date: 2024-02-02 11:08:41

Dicarbine Structure
Dicarbine structure
 Common Name Dicarbine
CAS Number 17411-19-7 Molecular Weight 202.30
Density 1.043g/cm3 Boiling Point 305.7ºC at 760mmHg
Molecular Formula C13H18N2 Melting Point N/A
MSDS N/A Flash Point 128.8ºC

 Use of Dicarbine


Dicarbine blocks dopamine receptors in various brain parts and prevents the depression of the conditioned defence reflexes caused by stimulation of the mesencephalic portion of the reticular formation. Dicarbine could be used to treat patients with schizophrenia and alcoholic psychosis in clinical[1][2].

 Names

Name 2,8-dimethyl-1,3,4,4a,5,9b-hexahydropyrido[4,3-b]indole
Synonym More Synonyms

 Dicarbine Biological Activity

Description Dicarbine blocks dopamine receptors in various brain parts and prevents the depression of the conditioned defence reflexes caused by stimulation of the mesencephalic portion of the reticular formation. Dicarbine could be used to treat patients with schizophrenia and alcoholic psychosis in clinical[1][2].
Related Catalog
Target

Dopamine receptor[1][2].

References

[1]. Barkov NK, et al. [Effect of carbidine on conditioned defense reflexes]. Biull Eksp Biol Med. 1975 Apr;79(4):61-4.

[2]. DICARBINE

 Chemical & Physical Properties

Density 1.043g/cm3
Boiling Point 305.7ºC at 760mmHg
Molecular Formula C13H18N2
Molecular Weight 202.30
Flash Point 128.8ºC
Exact Mass 202.14700
PSA 15.27000
LogP 2.28410
Vapour Pressure 0.000806mmHg at 25°C
Index of Refraction 1.554

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU9990175
CHEMICAL NAME :
1H-Pyrido(4,3-b)indole, 2,3,4,4a,5,9b-hexahydro-2,8-dimethyl-
CAS REGISTRY NUMBER :
17411-19-7
LAST UPDATED :
199712
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C13-H18-N2
MOLECULAR WEIGHT :
202.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
357 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3983239
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
153 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3983239
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
237 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3983239
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
79 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3983239

 Safety Information

HS Code 2933990090

 Synthetic Route

2,8-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole structure

2,8-Dimethyl-2,...

CAS#:19686-05-6

~%

Dicarbine Structure

Dicarbine

CAS#:17411-19-7

Literature: Kucherova, N. F.; Sipilina, N. M.; Novikova, N. N.; Silenko, I. D.; Rozenberg, S. G.; Zagorevskii, V. A. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980 , p. 1051 - 1053 Khimiya Geterotsiklicheskikh Soedinenii, 1980 , vol. 16, # 10 p. 1383 - 1386

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Carbidine
Dicarbine
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