4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene

Modify Date: 2024-02-01 18:35:03

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene structure	Common Name	4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
	CAS Number	174264-46-1	Molecular Weight	587.84400
	Density	1.15g/cm3	Boiling Point	706.195ºC at 760 mmHg
	Molecular Formula	C₃₄H₄₁NO₄SSi	Melting Point	N/A
	MSDS	N/A	Flash Point	380.893ºC

Use of 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4) is a reaction product of Raloxifene with tertbutyldimethylsilyl chloride. 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene is used to synthesize Raloxifene 6-glucuronide[1].

Name	[2-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-6-hydroxy-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
Synonym	More Synonyms

Description	4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4) is a reaction product of Raloxifene with tertbutyldimethylsilyl chloride. 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene is used to synthesize Raloxifene 6-glucuronide[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	The preparation of the Raloxifene 6-glucuronide includes: (a) reaction of Raloxifene with tertbutyldimethylsilyl chloride to give a chromatographically separable mixture of Compound 3 and 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4); (b) Lewis acid mediated coupling of phenol 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene with methyl1,2,3,4-tetra-O-acetyl-D-glucopyranuronate to provide a single product (Compound 6) with the desired flstereochemistry at the anomeric center; (c) heating Compound 6 with lithium hydroxide in dioxane to 60°C, followed by deprotection with tetrabutylammonium fluoride to give Raloxifene 6-glucuronide[1].
References	[1]. Dodge JA, et al. Evaluation of the major metabolites of raloxifene as modulators of tissue selectivity. J Steroid Biochem Mol Biol. 1997 Apr;61(1-2):97-106.

Density	1.15g/cm3
Boiling Point	706.195ºC at 760 mmHg
Molecular Formula	C₃₄H₄₁NO₄SSi
Molecular Weight	587.84400
Flash Point	380.893ºC
Exact Mass	587.25300
PSA	87.24000
LogP	8.69150
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.593