SB 218795

Modify Date: 2026-07-02 12:44:19

SB 218795 structure	Common Name	SB 218795
	CAS Number	174635-53-1	Molecular Weight	396.44
	Density	1.237g/cm3	Boiling Point	623.7ºC at 760 mmHg
	Molecular Formula	C₂₅H₂₀N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	331ºC

Use of SB 218795

SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit[1][2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	hNK3:13 nM (Ki) hNK2:1220 nM (Ki)
In Vitro	SB 218795 (3-30 nM) antagonizes the contractile responses induced by the NK3 receptor agonist senktide in a surmountable and concentration-dependent manner[2]. SB 218795 (0.3-3 μM) does not affect the contractile responses of the NK3 receptor agonist [MePhe7]-NKB in the rabbit iris sphincter muscle[2].
In Vivo	SB 218795 (0.25-1 mg/kg; i.v.) inhibits Senktide-induced miosis in rabbits by the maximum inhibition of 78%[2].
References	[1]. Giardina GA, et, al. Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework. J Med Chem. 1997 Jun 6;40(12):1794-807. [2]. Medhurst AD, et, al. In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists. Br J Pharmacol. 1997 Oct;122(3):469-76. [3]. Valero MS, et, al. Contractile effect of tachykinins on rabbit small intestine. Acta Pharmacol Sin. 2011 Apr;32(4):487-94.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.237g/cm3
Boiling Point	623.7ºC at 760 mmHg
Molecular Formula	C₂₅H₂₀N₂O₃
Molecular Weight	396.44
Flash Point	331ºC
Exact Mass	396.14700
PSA	68.29000
LogP	4.93680
Vapour Pressure	1.78E-15mmHg at 25°C
Index of Refraction	1.643
InChIKey	IUMQXQJZIHWLIN-HSZRJFAPSA-N
SMILES	COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1
Storage condition	-20°C

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

Acetophenone

CAS#:98-86-2

SB 218795

CAS#:174635-53-1

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Literature: Giardina, Giuseppe A. M.; Raveglia, Luca F.; Grugni, Mario; Sarau, Henry M.; Farina, Carlo; Medhurst, Andrew D.; Graziani, Davide; Schmidt, Dulcie B.; Rigolio, Roberto; Luttmann, Mark; Cavagnera, Stefano; Foley, James J.; Vecchietti, Vittorio; Hay, Douglas W. P. Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1053 - 1065

Cinchophen

CAS#:132-60-5

SB 218795

CAS#:174635-53-1

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Cinchophen

CAS#:132-60-5

H-D-Phg-OMe．HCl

CAS#:19883-41-1

SB 218795

CAS#:174635-53-1

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Literature: Giardina; Sarau; Farina; Medhurst; Grugni; Foley; Raveglia; Schmidt; Rigolio; Vassallo; Vecchietti; Hay Journal of Medicinal Chemistry, 1996 , vol. 39, # 12 p. 2281 - 2284

Cinchophen

CAS#:132-60-5

methyl (R)-amin...

CAS#:24461-61-8

SB 218795

CAS#:174635-53-1

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Literature: Giardina, Giuseppe A. M.; Sarau, Henry M.; Farina, Carlo; Medhurst, Andrew D.; Grugni, Mario; Raveglia, Luca F.; Schmidt, Dulcie B.; Rigolio, Roberto; Luttmann, Mark; Vecchietti, Vittorio; Hay, Douglas W. P. Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1794 - 1807

2-Phenylquinoli...

CAS#:59661-86-8

H-D-Phg-OMe．HCl

CAS#:19883-41-1

SB 218795

CAS#:174635-53-1

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This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 5
CAS#:98-86-2 Acetophenone CAS#:132-60-5 Cinchophen CAS#:19883-41-1 H-D-Phg-OMe．HCl CAS#:24461-61-8 methyl (R)-amin...
CAS#:59661-86-8 2-Phenylquinoli...
DownStream 0

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS

Name: qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay vali...
Source: NCGC
External Id: adst_MBL_Abs_LOPAC_o1

Name: NCATS Kinetic Aqueous Solubility Profiling
Source: NCGC
Target: N/A
External Id: ADME-solubility1

Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN

Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: qHTS Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2...
Source: NCGC
Target: ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens]
External Id: UBCH001

Name: Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8...
Source: ChEMBL
Target: Substance-K receptor
External Id: CHEMBL818109

Total 184, Current Page 1 of 19

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular weight of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate?

A: Molecular weight of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate is 396.44.

Q: What is the SMILES notation of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate?

A: SMILES notation of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate is COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1.

Q: What is the InChIKey of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate?

A: InChIKey of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate is IUMQXQJZIHWLIN-HSZRJFAPSA-N.

Q: What are the storage conditions for methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate?

A: Storage conditions for methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate: -20°C.

Q: What is the CAS number of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate?

A: CAS number of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate is 174635-53-1.

Q: What is the English name of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate?

A: The English name of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate is methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate.

Q: What are the upstream materials of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate?

A: Related upstream materials(CAS) of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate: 98-86-2;132-60-5;19883-41-1;24461-61-8;59661-86-8.

Q: What are the uses of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate?

A: Main uses of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate: SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit[1][2].

Q: What is the polar surface area (PSA) of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate?

A: Polar surface area (PSA) of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate is 68.29000.

Q: What is the LogP of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate?

A: LogP of methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate is 4.93680.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SB 218795
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: SB 218795
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.