CP 316311
Modify Date: 2025-09-13 15:19:14
CP 316311 structure
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Common Name | CP 316311 | ||
|---|---|---|---|---|
| CAS Number | 175139-41-0 | Molecular Weight | 327.46 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H29NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CP 316311CP 316311 is a potent and selective CRF1 receptor antagonist with an IC50 value of 6.8 nM. |
| Name | CP 316311 |
|---|
| Description | CP 316311 is a potent and selective CRF1 receptor antagonist with an IC50 value of 6.8 nM. |
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| Related Catalog | |
| Target |
IC50: 6.8 nM (CRF1 receptor)[1] |
| In Vitro | CP 316311 fully antagonizes CRF-stimulated adenylate cyclase activity in rat cortex and at human CRF1 receptors endogenously expressed in IMR32 cells with apparent Ki values of 7.6 and 8.5 nM, respectively[1]. |
| In Vivo | CP 316311 (3.2 mg/kg) inhibits 125I-oCRF binding by >80% in rats. CP 316311 significantly attenuates activation of the hypothalamic−pituitary−adrenal (HPA) axis, with an MED value of 10 mg/kg, p.o. CP 316311 blocks the effects of both the exogenous and endogenous CRF in the CNS. CP 316311 blocks the effects induced by the exogeneous or endogeneous CRF in the brain in rat models[1]. |
| References |
| Molecular Formula | C21H29NO2 |
|---|---|
| Molecular Weight | 327.46 |
| InChIKey | ZSEJGVQTBLJRCQ-UHFFFAOYSA-N |
| SMILES | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C |
| Storage condition | 2-8℃ |
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Name: Ex vivo displacement of [125I]oCRF from CRF1 receptor in Sprague-Dawley rat brain cor...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL935141
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Name: Ex vivo displacement of [125I]oCRF from CRF1 receptor in Sprague-Dawley rat pituitary...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL935142
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Name: Displacement of [125I]oCRF from rat CRF1 after 2 hrs by Betaplate scintillation count...
Source: ChEMBL
Target: Corticotropin-releasing factor receptor 1
External Id: CHEMBL935136
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Name: Displacement of ovine [125I]CRF from human CRF1 receptor expressed in CHO cells
Source: ChEMBL
Target: Corticotropin-releasing factor receptor 1
External Id: CHEMBL1764891
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Name: Dissociation constant, pKa of the compound
Source: ChEMBL
Target: N/A
External Id: CHEMBL935084
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Name: Displacement of [125]oCRF from rat cortex CRF1 receptor
Source: ChEMBL
Target: Corticotropin-releasing factor receptor 1
External Id: CHEMBL935083
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|
Name: Half life at terminal elimination phase in Beagle dog at 1.0 mg/kg, iv
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL934316
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Name: Attenuation of HPA axis activation in po dosed rat assessed as blockade of oCRF-induc...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL935092
|
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