Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1R,2R,5S,6R)-rel- (9CI)

Modify Date: 2025-09-26 14:19:25

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1R,2R,5S,6R)-rel- (9CI) structure	Common Name	Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1R,2R,5S,6R)-rel- (9CI)
	CAS Number	176027-90-0	Molecular Weight	185.18
	Density	1.6±0.1 g/cm3	Boiling Point	376.4±32.0 °C at 760 mmHg
	Molecular Formula	C₈H₁₁NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	181.4±25.1 °C

Use of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1R,2R,5S,6R)-rel- (9CI)

(rel)-Eglumegad ((rel)-LY354740) is the racemic isomer of Eglumegad (HY-18941). Eglumegad is a highly potent and selective group II (mGlu2/3) receptor agonist with EC50s of 5 and 24 nM for transfected human mGlu2 and mGlu3 receptors, respectively[1].

Name	Eglumetad
Synonym	More Synonyms

Description	(rel)-Eglumegad ((rel)-LY354740) is the racemic isomer of Eglumegad (HY-18941). Eglumegad is a highly potent and selective group II (mGlu2/3) receptor agonist with EC50s of 5 and 24 nM for transfected human mGlu2 and mGlu3 receptors, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR2[1]
References	[1]. Boerner T, et al. The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice. Eur J Neurosci. 2017 Apr;45(7):912- [2]. Orlando R, et al. Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740. Neuropharmacology. 2014 [3]. Procaccini C, et al. Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740. Neuroscience. 2013 Oct 10;250:189-200 [4]. Lee Y, et al. The mGlu2/3 receptor agonist LY354740 suppresses immobilization stress-induced increase in rat prefrontal cortical BDNF mRNA expression. Neurosci Lett. 2006 May 8;398(3):328-32.

Density	1.6±0.1 g/cm3
Boiling Point	376.4±32.0 °C at 760 mmHg
Molecular Formula	C₈H₁₁NO₄
Molecular Weight	185.18
Flash Point	181.4±25.1 °C
Exact Mass	185.068802
LogP	-1.22
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.619

8244

LY354740

MFCD04113018

UNII-ONU5A67T2S

ONU5A67T2S

(+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid

l-nebivolol

Eglumegad

Eglumetad

(1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)-

(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid

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Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1R,2R,5S,6R)-rel- (9CI)

Use of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1R,2R,5S,6R)-rel- (9CI)

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