Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1R,2R,5S,6R)-rel- (9CI)

Modify Date: 2025-09-26 14:19:25

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1R,2R,5S,6R)-rel- (9CI) structure	Common Name	Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1R,2R,5S,6R)-rel- (9CI)
	CAS Number	176027-90-0	Molecular Weight	185.18
	Density	1.6±0.1 g/cm3	Boiling Point	376.4±32.0 °C at 760 mmHg
	Molecular Formula	C₈H₁₁NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	181.4±25.1 °C

Use of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1R,2R,5S,6R)-rel- (9CI)

(rel)-Eglumegad ((rel)-LY354740) is the racemic isomer of Eglumegad (HY-18941). Eglumegad is a highly potent and selective group II (mGlu2/3) receptor agonist with EC50s of 5 and 24 nM for transfected human mGlu2 and mGlu3 receptors, respectively[1].

Name	Eglumetad
Synonym	More Synonyms

Description	(rel)-Eglumegad ((rel)-LY354740) is the racemic isomer of Eglumegad (HY-18941). Eglumegad is a highly potent and selective group II (mGlu2/3) receptor agonist with EC50s of 5 and 24 nM for transfected human mGlu2 and mGlu3 receptors, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR2[1]
References	[1]. Boerner T, et al. The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice. Eur J Neurosci. 2017 Apr;45(7):912- [2]. Orlando R, et al. Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740. Neuropharmacology. 2014 [3]. Procaccini C, et al. Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740. Neuroscience. 2013 Oct 10;250:189-200 [4]. Lee Y, et al. The mGlu2/3 receptor agonist LY354740 suppresses immobilization stress-induced increase in rat prefrontal cortical BDNF mRNA expression. Neurosci Lett. 2006 May 8;398(3):328-32.

Density	1.6±0.1 g/cm3
Boiling Point	376.4±32.0 °C at 760 mmHg
Molecular Formula	C₈H₁₁NO₄
Molecular Weight	185.18
Flash Point	181.4±25.1 °C
Exact Mass	185.068802
LogP	-1.22
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.619
InChIKey	VTAARTQTOOYTES-UHFFFAOYSA-N
SMILES	NC1(C(=O)O)CCC2C(C(=O)O)C21

Name: Tested for binding affinity against Metabotropic glutamate receptor 3 in CHO cells us...
Source: ChEMBL
Target: Metabotropic glutamate receptor 3
External Id: CHEMBL713034

Name: Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
Source: NCGC
External Id: IP6K1-p1

Name: Antagonist activity against Metabotropic glutamate receptor 3 expressed in CHO cells ...
Source: ChEMBL
Target: Metabotropic glutamate receptor 3
External Id: CHEMBL713037

Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802

Name: Inhibition of c-AMP by human Metabotropic glutamate receptor 8 (mGluR8) expressed in ...
Source: ChEMBL
Target: Metabotropic glutamate receptor 8
External Id: CHEMBL712468

Name: The effective concentration for 50% glutamate response was measured on Group I Metabo...
Source: ChEMBL
Target: N/A
External Id: CHEMBL680006

Name: Agonist activity at human recombinant mGlu2 receptor expressed in AV12 cells assessed...
Source: ChEMBL
Target: Metabotropic glutamate receptor 2
External Id: CHEMBL3619271

Name: Thermal Shift Assay. Domain: start/stop: M626-G740
Source: ChEMBL
Target: Peregrin
External Id: CHEMBL5062535

Name: Displacement of [3H]-459477 from human recombinant mGlu3 receptor expressed in AV12 c...
Source: ChEMBL
Target: Metabotropic glutamate receptor 3
External Id: CHEMBL3619270

Name: Displacement of [3H]-459477 from human recombinant mGlu2 receptor expressed in AV12 c...
Source: ChEMBL
Target: Metabotropic glutamate receptor 2
External Id: CHEMBL3619269

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8244

LY354740

MFCD04113018

UNII-ONU5A67T2S

ONU5A67T2S

(+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid

l-nebivolol

Eglumegad

Eglumetad

(1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid

(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid

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Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1R,2R,5S,6R)-rel- (9CI)

Use of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1R,2R,5S,6R)-rel- (9CI)

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