VH032-PEG5-C6-Cl (HaloPROTAC 2)
Modify Date: 2024-01-02 19:19:10
VH032-PEG5-C6-Cl (HaloPROTAC 2) structure
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Common Name | VH032-PEG5-C6-Cl (HaloPROTAC 2) | ||
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| CAS Number | 1799506-06-1 | Molecular Weight | 783.41 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C38H59ClN4O9S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VH032-PEG5-C6-Cl (HaloPROTAC 2)HaloPROTAC 2, a chloroalkane-containing PROTAC, induces degradation of HaloTag fusion proteins. |
| Name | HaloPROTAC 2 |
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| Description | HaloPROTAC 2, a chloroalkane-containing PROTAC, induces degradation of HaloTag fusion proteins. |
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| Related Catalog | |
| In Vitro | HaloPROTAC 1 and HaloPROTAC2, containing different linker lengths, are synthesized. Their ability to degrade GFP-HaloTag7, (stably expressed in HEK 293 cells) is tested tby flow cytometry, measuring changes in mean fluorescence intensity. While 24 hour treatment with HaloPROTAC 1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM[1]. |
| References |
| Molecular Formula | C38H59ClN4O9S |
|---|---|
| Molecular Weight | 783.41 |