ATP-polyamine-biotin

Modify Date: 2024-01-02 12:30:23

ATP-polyamine-biotin Structure
ATP-polyamine-biotin structure
Common Name ATP-polyamine-biotin
CAS Number 1800401-93-7 Molecular Weight 945.854
Density 1.8±0.1 g/cm3 Boiling Point N/A
Molecular Formula C32H58N11O14P3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ATP-polyamine-biotin


APB is a cell-permeable, efficient kinase cosubstrate with conversions and kinetics similar to those of other known ATP analogues. APB shows a cytotoxicity EC50 value of 19 ± 1 mM.APB is shown to promote biotin labeling of kinase substrates in live cells and has future applications in phosphoprotein purification and analysis. APB is cell-permeable and nontoxic at low mM concentrations, with cell penetration and labeling dependent on the polyamine linker.

 Names

Name ATP-polyamine-biotin
Synonym More Synonyms

 ATP-polyamine-biotin Biological Activity

Description APB is a cell-permeable, efficient kinase cosubstrate with conversions and kinetics similar to those of other known ATP analogues. APB shows a cytotoxicity EC50 value of 19 ± 1 mM.APB is shown to promote biotin labeling of kinase substrates in live cells and has future applications in phosphoprotein purification and analysis. APB is cell-permeable and nontoxic at low mM concentrations, with cell penetration and labeling dependent on the polyamine linker.
Related Catalog
References

[1]. Fouda AE, Pflum MK. A Cell-Permeable ATP Analogue for Kinase-Catalyzed Biotinylation. Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9618-21.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Molecular Formula C32H58N11O14P3S
Molecular Weight 945.854
Exact Mass 945.309814
LogP -3.53
Index of Refraction 1.730
Storage condition -20℃

 Synonyms

Adenosine, 5'-O-[[[[[[[3-[[4-[[3-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]propyl]methylamino]butyl]methylamino]propyl]amino]hydroxyphosphinyl]oxy]hydroxyphosphinyl]oxy]hydroxyphosphinyl]-
5'-O-{Hydroxy[(hydroxy{[hydroxy({3-[methyl(4-{methyl[3-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)propyl]amino}butyl)amino]propyl}amino)phosphoryl]oxy}phosphoryl)oxy]phosphoryl}adenosine