SDZ NKT 343

Modify Date: 2024-01-09 09:59:58

SDZ NKT 343 structure	Common Name	SDZ NKT 343
	CAS Number	180046-99-5	Molecular Weight	579.64600
	Density	1.327g/cm3	Boiling Point	892.8ºC at 760mmHg
	Molecular Formula	C₃₃H₃₃N₅O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	493.8ºC

Use of SDZ NKT 343

SDZ NKT 343 is a selective, orally active NK1 receptor antagonist with an IC50 of 0.62 nM against human NK1 receptor. SDZ NKT 343 has good analgesic activity[1][2].

Name	(2S)-2-N-[(2S)-1-[benzyl(methyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-1-N-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
Synonym	More Synonyms

Description	SDZ NKT 343 is a selective, orally active NK1 receptor antagonist with an IC50 of 0.62 nM against human NK1 receptor. SDZ NKT 343 has good analgesic activity[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	hNK1:0.62 nM (IC50) hNK2:0.52 μM (Ki) hNK3:3.4 μM (Ki)
In Vitro	SDZ NKT 343 shows a markedly lower affinity at rat NK1 receptors in whole forebrain membranes (IC50=451+139 nM)[1]. SDZ NKT 343 shows weak affinity to human NK2 and NK3 receptors in transfected Cos-7 cells (Ki of 0.52+0.04 μM and 3.4+1.2 μM respectively)[1].
In Vivo	SDZ NKT 343 antagonized [Sar9]SP sulphone-evoked bronchoconstriction (70% reduction at 0.4 mg/kg, i.v.) in anaesthetized guinea-pigs[1].
References	[1]. Walpole CS, et al. Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor antagonist. Br J Pharmacol. 1998 May;124(1):83-92. [2]. Walpole C, et al. 2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N - methylamide (SDZ NKT 343), a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic pain models. J Med Chem. 1998 Aug 13;41(17):3159-73.

Density	1.327g/cm3
Boiling Point	892.8ºC at 760mmHg
Molecular Formula	C₃₃H₃₃N₅O₅
Molecular Weight	579.64600
Flash Point	493.8ºC
Exact Mass	579.24800
PSA	127.57000
LogP	6.05540
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.676

Lauryl-LF 11

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-[[(2-NITROPHENYL)AMINO]CARBONYL]-L-PROLYL-N-METHYL-3-(2-NAPHTHALENYL)-N-(PHENYLMETHYL)-L-ALANINAMIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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