S-22153
Modify Date: 2024-01-03 17:48:16
S-22153 structure
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Common Name | S-22153 | ||
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| CAS Number | 180304-07-8 | Molecular Weight | 247.35600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H17NOS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of S-22153S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes[1][2]. |
| Name | N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide |
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| Description | S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes[1][2]. |
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| Related Catalog | |
| Target |
MT1:19 nM (EC50) MT2:4.6 nM (EC50) |
| In Vivo | S-22153 sets the temperature and activity periods to approximately 24 hr and increase the circadian amplitude of both rhythms in mice, which exposed to continuous light[1] . Animal Model: 7 weeks old Male B6D2F1 mice, which exposed to continuous light for 10-18 days[1] Dosage: 20 mg/kg Administration: Daily intraperitoneal (i.p.) for 19 days Result: Set the temperature and activity periods to approximately 24 hr and increased the circadian amplitude of both rhythms in mice, which exposed to continuous light. |
| References |
| Molecular Formula | C14H17NOS |
|---|---|
| Molecular Weight | 247.35600 |
| Exact Mass | 247.10300 |
| PSA | 60.83000 |
| LogP | 3.98260 |