S-22153
S-22153 structure
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Common Name | S-22153 | ||
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| CAS Number | 180304-07-8 | Molecular Weight | 247.35600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H17NOS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of S-22153S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide |
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This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes[1][2]. |
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| Related Catalog | |
| Target |
MT1:19 nM (EC50) MT2:4.6 nM (EC50) |
| In Vivo | S-22153 sets the temperature and activity periods to approximately 24 hr and increase the circadian amplitude of both rhythms in mice, which exposed to continuous light[1] . Animal Model: 7 weeks old Male B6D2F1 mice, which exposed to continuous light for 10-18 days[1] Dosage: 20 mg/kg Administration: Daily intraperitoneal (i.p.) for 19 days Result: Set the temperature and activity periods to approximately 24 hr and increased the circadian amplitude of both rhythms in mice, which exposed to continuous light. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C14H17NOS |
|---|---|
| Molecular Weight | 247.35600 |
| Exact Mass | 247.10300 |
| PSA | 60.83000 |
| LogP | 3.98260 |
| InChIKey | PICRXJDULXLJCZ-UHFFFAOYSA-N |
| SMILES | CCc1ccc2scc(CCNC(C)=O)c2c1 |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Human MT2 receptor (Melatonin receptors)
Source: IUPHAR-DB
Target: MT2 receptor (Melatonin receptors) [Homo sapiens]
External Id: 288_Human
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Name: Human MT1 receptor (Melatonin receptors)
Source: IUPHAR-DB
Target: MT1 receptor (Melatonin receptors) [Homo sapiens]
External Id: 287_Human
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This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular formula of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide? |
| A: Molecular formula of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide is C14H17NOS. |
| Q: What is the polar surface area (PSA) of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide? |
| A: Polar surface area (PSA) of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide is 60.83000. |
| Q: What is the InChIKey of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide? |
| A: InChIKey of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide is PICRXJDULXLJCZ-UHFFFAOYSA-N. |
| Q: What is the CAS number of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide? |
| A: CAS number of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide is 180304-07-8. |
| Q: What is the Chinese name of 180304-07-8? |
| A: Chinese name of 180304-07-8 is 180304-07-8. |
| Q: What are the uses of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide? |
| A: Main uses of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide: S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes[1][2]. |
| Q: What is the English name of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide? |
| A: The English name of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide is N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide. |
| Q: What is the LogP of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide? |
| A: LogP of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide is 3.98260. |
| Q: What is the SMILES notation of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide? |
| A: SMILES notation of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide is CCc1ccc2scc(CCNC(C)=O)c2c1. |
| Q: What is the molecular weight of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide? |
| A: Molecular weight of N-[2-(5-Ethyl-1-benzothiophen-3-yl)ethyl]acetamide is 247.35600. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |