BP-5-087
Modify Date: 2025-09-25 16:36:23
BP-5-087 structure
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Common Name | BP-5-087 | ||
|---|---|---|---|---|
| CAS Number | 1803281-30-2 | Molecular Weight | 770.691 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C36H30F8N2O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BP-5-087A potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation; restores TKI sensitivity to therapy-resistant CML progenitor cells in primary cells from CML patients with BCR-ABL1 kinase-independent TKI resistance, including leukemic stem cells. |
| Name | BP-5-087 |
|---|
| Description | A potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation; restores TKI sensitivity to therapy-resistant CML progenitor cells in primary cells from CML patients with BCR-ABL1 kinase-independent TKI resistance, including leukemic stem cells. |
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| References | References 1. Eiring AM, et al. Leukemia. 2015 Mar;29(3):586-597. 2. Eiring AM, et al. Leuk Suppl. 2014 Dec;3(Suppl 1):S5-6. View Related Products by Target STAT |
| Molecular Formula | C36H30F8N2O6S |
|---|---|
| Molecular Weight | 770.691 |
| InChIKey | TUASQDVQXOJGIE-UHFFFAOYSA-N |
| SMILES | O=C(O)c1ccc(N(Cc2ccc(C3CCCCC3)cc2)C(=O)CN(Cc2c(F)c(F)c(F)c(F)c2F)S(=O)(=O)c2ccc(C(F)(F)F)cc2)cc1O |