NTNT 185
Modify Date: 2024-01-12 18:30:44
NTNT 185 structure
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Common Name | NTNT 185 | ||
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| CAS Number | 1804978-82-2 | Molecular Weight | 688.66 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C33H39Cl2N5O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NTNT 185YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models[1][2]. |
| Name | YNT-185 dihydrochloride |
|---|
| Description | YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models[1][2]. |
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| Related Catalog | |
| Target |
OX2 Receptor:0.028 μM (EC50) OX1 Receptor:2.75 μM (EC50) |
| In Vivo | YNT-185 dihydrochloride (20-40 mg/kg; i.p.) increases wakefulness in mice[2]. YNT-185 (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice[2]. Animal Model: Male wild-type C57BL/6J mice[2] Dosage: 20, 40 mg/kg Administration: I.p. Result: Wake time was also significantly increased. |
| References |
| Molecular Formula | C33H39Cl2N5O5S |
|---|---|
| Molecular Weight | 688.66 |