Bromoacetamido-PEG4-acid structure
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Common Name | Bromoacetamido-PEG4-acid | ||
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CAS Number | 1807518-67-7 | Molecular Weight | 386.236 | |
Density | 1.4±0.1 g/cm3 | Boiling Point | 557.7±50.0 °C at 760 mmHg | |
Molecular Formula | C13H24BrNO7 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 291.1±30.1 °C |
Use of Bromoacetamido-PEG4-acidBromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
Name | 1-Bromo-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid |
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Synonym | More Synonyms |
Description | Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
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Related Catalog | |
Target |
PEGs Cleavable |
In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
References |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 557.7±50.0 °C at 760 mmHg |
Molecular Formula | C13H24BrNO7 |
Molecular Weight | 386.236 |
Flash Point | 291.1±30.1 °C |
Exact Mass | 385.073608 |
LogP | -1.31 |
Vapour Pressure | 0.0±3.3 mmHg at 25°C |
Index of Refraction | 1.494 |
Hazard Codes | Xi |
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1-Bromo-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid |
6,9,12,15-Tetraoxa-3-azaoctadecan-18-oic acid, 1-bromo-2-oxo- |
MFCD28950779 |