Ono 3403
Modify Date: 2026-06-26 17:47:30
Ono 3403 structure
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Common Name | Ono 3403 | ||
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| CAS Number | 181586-07-2 | Molecular Weight | 545.6 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H31N3O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Ono 3403Ono 3403 is a synthetic serine protease inhibitor. Ono 3403 inhibits lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production. ONO-3403 also has an antitumor effect on malignant tumors. |
| Name | Ono 3403 |
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| Description | Ono 3403 is a synthetic serine protease inhibitor. Ono 3403 inhibits lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production. ONO-3403 also has an antitumor effect on malignant tumors. |
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| References | 1. Tumurkhuu G, Koide N, Hiwasa T, Ookoshi M, Dagvadorj J, Abu Shadat Mohammod Noman, Iftakhar-E-Khuda I, Naiki Y, Komatsu T, Yoshida T, Yokochi T. ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Innate Immun. 2011 Feb;17(1):97-105. doi: 10.1177/1753425909353641. Epub 2009 Dec 18. PubMed PMID: 20023007. |
| Molecular Formula | C26H31N3O8S |
|---|---|
| Molecular Weight | 545.6 |
| InChIKey | PKBZGVVSSNNHGY-INTLEYBYSA-N |
| SMILES | C=CCN(CC(=O)OCC)C(=O)C(C)=Cc1ccc(C(=O)Oc2ccc(C(=N)N)cc2)cc1.CS(=O)(=O)O |
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Name: Half-life in dog small intestine homogenate.
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL642596
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Name: Half-life in rat small intestine homogenate.
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL875063
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Name: Half-life in rat liver homogenate.
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL642418
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Name: Half-life in dog liver homogenate.
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL642594
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Name: Half-life in dog plasma.
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL642595
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