UNC4203
Modify Date: 2024-04-03 14:02:56
UNC4203 structure
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Common Name | UNC4203 | ||
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| CAS Number | 1818234-19-3 | Molecular Weight | 504.710 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 682.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C30H44N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 366.3±34.3 °C | |
Use of UNC4203UNC4203 (UNC-4203) is a potent, highly selective MerTK with IC50 of 2.4 nM, displays >30- and 4 -foldfold selectivity over Alx (IC50=80 nM) and Tyro3 (IC50=9.1 nM); display IC50 of 39 nM for FLT-3, inhibits MERTK phosphorylation in cell-based assays with IC50 of 13.8 nM, inhibits MERTK phosphorylation in vivo in mice with advanced leukemia (30 mg/kg, ip injection). |
| Name | trans-4-(5-{4-[(4-Methyl-1,4-diazepan-1-yl)methyl]phenyl}-2-[(2S)-2-pentanylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol |
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| Synonym | More Synonyms |
| Description | UNC4203 (UNC-4203) is a potent, highly selective MerTK with IC50 of 2.4 nM, displays >30- and 4 -foldfold selectivity over Alx (IC50=80 nM) and Tyro3 (IC50=9.1 nM); display IC50 of 39 nM for FLT-3, inhibits MERTK phosphorylation in cell-based assays with IC50 of 13.8 nM, inhibits MERTK phosphorylation in vivo in mice with advanced leukemia (30 mg/kg, ip injection). |
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| References | References 1. Zhao J, et al. J Med Chem. 2018 Nov 5. doi: 10.1021/acs.jmedchem.8b01229. View Related Products by Target TAM Receptor (Tyro3-Axl-Mer) |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 682.0±65.0 °C at 760 mmHg |
| Molecular Formula | C30H44N6O |
| Molecular Weight | 504.710 |
| Flash Point | 366.3±34.3 °C |
| Exact Mass | 504.357666 |
| LogP | 4.18 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.642 |
| trans-4-(5-{4-[(4-Methyl-1,4-diazepan-1-yl)methyl]phenyl}-2-[(2S)-2-pentanylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol |
| Cyclohexanol, 4-[5-[4-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)methyl]phenyl]-2-[[(1S)-1-methylbutyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans- |