SPHINX31

Modify Date: 2024-01-05 16:21:14

SPHINX31 Structure
SPHINX31 structure
Common Name SPHINX31
CAS Number 1818389-84-2 Molecular Weight 507.51
Density N/A Boiling Point N/A
Molecular Formula C27H24F3N5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SPHINX31


SPHINX31 is a potent and selective inhibitor of serine/arginine-rich protein kinase 1 (SRPK1), with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), which is a SRPK1 substrate. SPHINX31 is a potential topical therapeutic for neovascular eye disease[1].

 Names

Name SPHINX31

 SPHINX31 Biological Activity

Description SPHINX31 is a potent and selective inhibitor of serine/arginine-rich protein kinase 1 (SRPK1), with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), which is a SRPK1 substrate. SPHINX31 is a potential topical therapeutic for neovascular eye disease[1].
Related Catalog
Target

IC50: 5.9 nM (SRPK1)[1].

References

[1]. Batson J, et al. Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem Biol. 2017 Mar 17;12(3):825-832.

 Chemical & Physical Properties

Molecular Formula C27H24F3N5O2
Molecular Weight 507.51
Storage condition 2-8℃