KC 12291 hydrochloride

Modify Date: 2024-04-02 11:37:59

KC 12291 hydrochloride Structure
KC 12291 hydrochloride structure
Common Name KC 12291 hydrochloride
CAS Number 181936-98-1 Molecular Weight 449.99
Density N/A Boiling Point N/A
Molecular Formula C22H28ClN3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of KC 12291 hydrochloride


KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na+ current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo[1].

 Names

Name N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methyl-3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propan-1-amine,hydrochloride
Synonym More Synonyms

 KC 12291 hydrochloride Biological Activity

Description KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na+ current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo[1].
Related Catalog
References

[1]. John GW, et al. KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc Drug Rev. 2004 Spring;22(1):17-26.  

 Chemical & Physical Properties

Molecular Formula C22H28ClN3O3S
Molecular Weight 449.99
Exact Mass 449.15400
PSA 84.95000
LogP 4.96770

 Safety Information

HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Xamoterol hemifumarate
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