Derazantinib dihydrochloride
Modify Date: 2025-08-25 12:20:29
Derazantinib dihydrochloride structure
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Common Name | Derazantinib dihydrochloride | ||
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| CAS Number | 1821329-75-2 | Molecular Weight | 541.487 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H31Cl2FN4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Derazantinib dihydrochlorideDerazantinib (ARQ-087) dihydrochloride is an ATP competitive and orally activeFGFR inhibitor (IC50s: 1.8 nM for FGFR2, 4.5 nM for FGFR1 and 3). Derazantinib dihydrochloride inhibits FGFR phosphorylation. Derazantinib dihydrochloride inhibits tumor growth in multiple xenograft models[1][2]. |
| Name | ARQ-087 dihydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Derazantinib (ARQ-087) dihydrochloride is an ATP competitive and orally activeFGFR inhibitor (IC50s: 1.8 nM for FGFR2, 4.5 nM for FGFR1 and 3). Derazantinib dihydrochloride inhibits FGFR phosphorylation. Derazantinib dihydrochloride inhibits tumor growth in multiple xenograft models[1][2]. |
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| Related Catalog | |
| Target |
1.8 nM for FGFR2, 4.5 nM for FGFR1 and 3 nM[1] |
| References |
| Molecular Formula | C29H31Cl2FN4O |
|---|---|
| Molecular Weight | 541.487 |
| Exact Mass | 540.185913 |
| Benzo[h]quinazolin-2-amine, 6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-, (6R)-, hydrochloride (1:2) |
| (6R)-6-(2-Fluorophenyl)-N-(3-{2-[(2-methoxyethyl)amino]ethyl}phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine dihydrochloride |
| U6B7J0L31Q |