Exatecan Intermediate 2

Modify Date: 2025-08-26 21:38:06

Exatecan Intermediate 2 Structure
Exatecan Intermediate 2 structure
Common Name Exatecan Intermediate 2
CAS Number 182182-31-6 Molecular Weight 250.27
Density N/A Boiling Point N/A
Molecular Formula C13H15FN2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Exatecan Intermediate 2


Exatecan Intermediate 2 (compound B) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers[1][2].

 Names

Name N-(8-amino-6-fluoro-5-methyl-1-oxo-3,4-dihydro-2H-naphthalen-2-yl)acetamide
Synonym More Synonyms

 Exatecan Intermediate 2 Biological Activity

Description Exatecan Intermediate 2 (compound B) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers[1][2].
Related Catalog
References

[1]. Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973.  

[2]. Lv Xianyu, et al. Preparation of camptothecin derivative intermediate. China, CN115197088. 2022-10-18.

 Chemical & Physical Properties

Molecular Formula C13H15FN2O2
Molecular Weight 250.27
Exact Mass 250.11200
PSA 75.68000
LogP 2.77140

 Synonyms

2-acetylamino-8-amino-6-fluoro-5-methyl-l-tetralone
2-Acetylamino-8-amino-6-fluoro-5-methyl-1-tetralone
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