Monomethyl auristatin E intermediate-5

Modify Date: 2025-09-20 16:39:03

Monomethyl auristatin E intermediate-5 Structure
Monomethyl auristatin E intermediate-5 structure
 Common Name Monomethyl auristatin E intermediate-5
CAS Number 1822810-13-8 Molecular Weight 349.42
Density 1.100±0.06 g/cm3(Predicted) Boiling Point 464.4±35.0 °C(Predicted)
Molecular Formula C19H27NO5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Monomethyl auristatin E intermediate-5


Monomethyl auristatin E intermediate-5 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

 Names

Name tert-Butyl 4-(((benzyloxy)carbonyl)amino)-5-methyl-3-oxohexanoate

 Monomethyl auristatin E intermediate-5 Biological Activity

Description Monomethyl auristatin E intermediate-5 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
Related Catalog
References

[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.  

 Chemical & Physical Properties

Density 1.100±0.06 g/cm3(Predicted)
Boiling Point 464.4±35.0 °C(Predicted)
Molecular Formula C19H27NO5
Molecular Weight 349.42
InChIKey FGKFTCDIARXOCS-UHFFFAOYSA-N
SMILES CC(C)C(NC(=O)OCc1ccccc1)C(=O)CC(=O)OC(C)(C)C
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