JJH260

Modify Date: 2024-09-03 08:31:06

JJH260 Structure
JJH260 structure
Common Name JJH260
CAS Number 1831135-30-8 Molecular Weight 568.06
Density 1.4±0.1 g/cm3 Boiling Point 703.9±70.0 °C at 760 mmHg
Molecular Formula C29H34ClN5O5 Melting Point N/A
MSDS N/A Flash Point 379.5±35.7 °C

 Use of JJH260


JJH260 is AIG1inhibitor, and inhibit the fluorophosphonate reactivity and fatty acid esters of hydroxy fatty acid (FAHFA) hydrolysis activity of AIG1in HEK293T cells, with IC50 values of 0.50 μM and 0.57 μM, respectively[1].

 Names

Name JJH260
Synonym More Synonyms

 JJH260 Biological Activity

Description JJH260 is AIG1inhibitor, and inhibit the fluorophosphonate reactivity and fatty acid esters of hydroxy fatty acid (FAHFA) hydrolysis activity of AIG1in HEK293T cells, with IC50 values of 0.50 μM and 0.57 μM, respectively[1].
Related Catalog
Target

0.50 μM (AIG1) and 0.57 μM (FAHFA) in HEK293T cells [1]

References

[1]. William H Parsons, et al. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nat Chem Biol. 2016 May;12(5):367-372.  

[2]. Xinkang Wang, et al. Antithrombotic Effects of the Novel Small-Molecule Factor XIa Inhibitor Milvexian in a Rabbit Arteriovenous Shunt Model of Venous Thrombosis. TH Open. 2023 Apr; 7(2): e97–e104.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 703.9±70.0 °C at 760 mmHg
Molecular Formula C29H34ClN5O5
Molecular Weight 568.06
Flash Point 379.5±35.7 °C
Exact Mass 567.224854
LogP 2.99
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.662

 Synonyms

Imidazo[1,5-a]pyrazine-1,3(2H,5H)-dione, 2-[[[4-[2-(4-chlorophenyl)ethyl]-1-piperidinyl]carbonyl]oxy]-7-[4-(dimethylamino)benzoyl]tetrahydro-
2-[({4-[2-(4-Chlorophenyl)ethyl]-1-piperidinyl}carbonyl)oxy]-7-[4-(dimethylamino)benzoyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione
JJH260