(Pyr3)-Amyloid β-Protein (3-42) ammonium salt

Modify Date: 2025-08-25 15:28:40

(Pyr3)-Amyloid β-Protein (3-42) ammonium salt Structure
(Pyr3)-Amyloid β-Protein (3-42) ammonium salt structure
Common Name (Pyr3)-Amyloid β-Protein (3-42) ammonium salt
CAS Number 183449-57-2 Molecular Weight 4309.86
Density N/A Boiling Point N/A
Molecular Formula C196H299N53O55S Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of (Pyr3)-Amyloid β-Protein (3-42) ammonium salt


(Pyr3)-Amyloid β-Protein (3-42) is the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. (Pyr3)-Amyloid β-Protein (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits[1].

 Names

Name [pGlu3]-Amyloid β-Protein Fragment 3-42
Synonym More Synonyms

  Biological Activity

Description (Pyr3)-Amyloid β-Protein (3-42) is the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. (Pyr3)-Amyloid β-Protein (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits[1].
Related Catalog
References

[1]. Takahashi-Ito K, et.al. Memantine inhibits β-amyloid aggregation and disassembles preformed β-amyloid aggregates. Biochem Biophys Res Commun. 2017 Nov 4;493(1):158-163.  

 Chemical & Physical Properties

Molecular Formula C196H299N53O55S
Molecular Weight 4309.86
Exact Mass 4307.19000
PSA 1722.65000
LogP 5.49010
Appearance of Characters solid
InChIKey KGOBZCKPDJHJMH-UHFFFAOYSA-N
SMILES CCC(C)C(NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)CNC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCC(N)=O)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(NC(=O)C(CCC(=O)O)NC(=O)C(Cc1ccc(O)cc1)NC(=O)CNC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(CCCNC(=N)N)NC(=O)C(Cc1ccccc1)NC(=O)C1CCC(=O)N1)C(C)C)C(C)C)C(C)C)C(=O)NC(C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C)C(=O)O)C(C)CC)C(C)C)C(C)C)C(C)C)C(C)CC
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Synonyms

pyr-phe-arg-his-asp-ser-gly-tyr-glu-val-his-his-gln-lys-leu-val-phe-phe-ala-glu-asp-val-gly-ser-asn-lys-gly-ala-ile-ile-gly-leu-met-val-gly-gly-val-val-ile-ala trifluoroacetate
MFCD03457978
Pyr-FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
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