E3 ligase Ligand-Linker Conjugates 9

Modify Date: 2024-01-03 17:50:51

E3 ligase Ligand-Linker Conjugates 9 structure	Common Name	E3 ligase Ligand-Linker Conjugates 9
	CAS Number	1835705-59-3	Molecular Weight	827.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₀H₆₃ClN₄O₁₀S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of E3 ligase Ligand-Linker Conjugates 9

E3 ligase Ligand-Linker Conjugates 9 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.

Name	E3 ligase Ligand-Linker Conjugates 9

Description	E3 ligase Ligand-Linker Conjugates 9 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
Related Catalog	Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate Research Areas >> Cancer
Target	E3 Ligase Ligand-Linker Conjugate[1]
In Vitro	E3 ligase Ligand-Linker Conjugates 9 uses the VHL ligand[1]. The linker is 6-2-2-2-2-2-2. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. E3 ligase Ligand-Linker Conjugates 9 can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase [2].
References	[1]. US 20170121321 A1 [2]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.

Molecular Formula	C₄₀H₆₃ClN₄O₁₀S
Molecular Weight	827.47
Storage condition	2-8℃

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China
Product Name: (S,R,S)-AHPC-PEG6-C4-Cl
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