BNM-III-170

Modify Date: 2024-03-04 10:44:43

BNM-III-170 Structure
BNM-III-170 structure
Common Name BNM-III-170
CAS Number 1859189-54-0 Molecular Weight 446.911
Density N/A Boiling Point N/A
Molecular Formula C21H24ClFN6O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BNM-III-170


BNM-III-170 is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo; binds the HIV-1 gp120 Env and promotes conformational changes similar to those induced by CD4, exposing conserved Env elements to antibodies; synergizes with antibodies elicited by monomeric HIV-1 gp120 to protect monkeys from multiple high-dose intrarectal challenges with a heterologous simian-human immunodeficiency virus (SHIV).

 Names

Name BNM-III-170

 BNM-III-170 Biological Activity

Description BNM-III-170 is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo; binds the HIV-1 gp120 Env and promotes conformational changes similar to those induced by CD4, exposing conserved Env elements to antibodies; synergizes with antibodies elicited by monomeric HIV-1 gp120 to protect monkeys from multiple high-dose intrarectal challenges with a heterologous simian-human immunodeficiency virus (SHIV).
References References 1. Madani N, et al. Nat Commun. 2018 Jun 18;9(1):2363. View Related Products by Target HIV

 Chemical & Physical Properties

Molecular Formula C21H24ClFN6O2
Molecular Weight 446.911